Effects of Xanthium sibiricum oil drops on behavioral symptom and serum IL-5 level in mice with allergic rhinitis
Objective To observe the effects of Xanthium sibiricum oil drops on behavioral symptom and serum IL-5 level in mice with allergic rhinitis.Methods Thirty-two SPF grade BALB/c male mice were randomly divided into the normal group,the model group,the control group and the experimental group,with 8 mice in each group.Except for the normal group,the other three groups were sensitized with ovalbumin to establish a mouse model of allergic rhinitis.After the model was successfully es-tablished,the experimental group used Xanthium sibiricum oil drops,the control group used Cetirizine drops,and the other two groups used normal saline nasal drops.The course of treatment was 9 days.After the treatment,the nasal behavioral symptom was scored and serum IL-5 level was detected by using ELISA.Results Compared with that of the model group,the behavioral symptom score of the control group slightly increased(P＜0.05),while the behavioral symptom score of the experimental group decreased(P＜0.05).The serum IL-5 levels of both the control and experimental groups decreased(P＜0.01).Compared with that of the control group,the behavioral symptom score of the experimental group decreased(P＜0.05),and serum IL-5 level also decreased(P＞0.05).Conclusion Xanthium sibiricum oil drops could improve the nasal behavioral symptom and reduce serum IL-5 level in mice with allergic rhinitis.
万方数据
维普
