Objective To investigate the serum levels of syndecan-1(SDC-1),heparan sulfate(HS)and heparanase(HPA)in patients with non-small cell lung cancer(NSCLC)and small cell lung cancer(SCLC),and diagnostic and predictive value.Methods We collected serum samples from 10 healthy volunteers and 76 lung cancer patients,and detected the expres-sion of HS,SDC-1 and HPA in serum by ELISA.Mann-Whitney Utest is used to compare with each group.Results The serum levels of HS,SDC-1 and HPA in lung cancer patients were higher than those in healthy volunteers.The AUC of HS and HPA in the diagnosis of lung cancer was 0.819 and 0.930 respectively.The AUC of HS,SDC-1 and HPA in the diagnosis of lung cancer was 0.974.Conclusion Co-detection of HS,HPA and SDC-1 could have important diagnostic and predictive value for lung canc-er.
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