Objective To investigate the effects of PERMA nursing intervention on exercise fear and mental resilience of pa-tients after acute myocardial percutaneous coronary intervention(PCI).Methods One hundred and sixty patients after emergen-cy PCI were selected as the study objects,and were randomly divided into the control group(80 patients)and the observation group(80 patients).The control group received routine nursing,and the observation group received nursing intervention based on PERMA model on the basis of routine nursing.Exercise fear scale and mental resilience scale were used to evaluate the effects on the second day of admission and 6 weeks after the intervention.Results After 6 weeks of nursing intervention,four scores of fear of injury,self-function decline,avoidance of exercise and perceived heart risk and total score of the TSK-Heart-C scale in the observation group were significantly reduced,and the total score of the observation group after intervention was lower than that of the control group,P<0.05.After nursing intervention,the scores of tenacity,self-reliance and optimism and the total score in the CD-RISC scale of the observation group were increased,all P<0.05,and the above scores in the observation group were higher than those in the control group,P<0.01.Conclusion Nursing intervention based on PERMA model can effectively re-duce the degree of exercise fear and improve the level of psychological resilience of patients,which is of great significance for im-proving cardiac rehabilitation of patients after emergency PCI.