摘要
目的 分析皮肤黑色素瘤患者生存时间的影响因素,探究改善预后的措施,以达到降低患者的病死率、减轻疾病负担的目的.方法 筛选SEER数据库中的患者数据,运用卡方检验进行结局的单变量分析;使用Kaplan-Meier法绘制生存曲线,采用log-rank法进行生存时间的比较;运用Cox比例风险模型进行生存时间影响因素的多因素分析.结果 不同性别、年龄、家庭收入、TNM分期、临床分期、肿瘤分级组的生存时间之间的差别存在统计学意义(P<0.0001).女性的死亡风险是男性的0.782倍;年龄越大、家庭收入越低的患者死亡风险越大;邻近组织和淋巴结受累情况越严重,患者预后情况越差;癌症转移后生存率明显下降.结论 男性、年龄大、家庭收入低、临床分期高、肿瘤分级高的患者死亡风险较大.建议每5年对50岁以上的男性进行一次筛查;在低收入社区开展教育活动,以缩小地区的预后差距.
Abstract
Objective To analyze the influencing factors of survival time for cutaneous melanoma patients,to explore the measures for improving the prognosis,so as to achieve the purpose of reducing the mortality of patients and reducing the burden of disease.Methods Patient data in the Surveillance,Epidemiology,and End Results (SEER)database were screened,and univariate analysis of outcome was carried out using Chi-square test;Kaplan-Meier method was used to draw the survival curve,and log-rank method was used to compare the survival time;the Cox proportional risk model was used to analyze the multi-factors influencing survival time. Results There were statistically significant differences between gender,age,family income,TNM stage,clinical stage,and survival time in the tumor grade group (P<0. 0001). The mortality risk for females is 0. 782 times that of males;the older the patients and the lower the family income,the greater the risk of death;the more severe the involve-ment of adjacent tissues and lymph nodes,the worse the prognosis of the patients;survival rates after cancer metastasis signifi-cantly reduced. Conclusion Male,older,lower family income,higher clinical stage,and high tumor grade in patients have higher risk of death. It is recommended that men over the age of 50 should be screened every 5 years and educational activities in low-income communities should be carried out to narrow the regional prognostic gaps.
基金项目
山东省统计科学应用研究课题重点项目(2023TJZD005)
滨州医学院2021年教学改革与研究项目(JYKTMS2021059)
滨州医学院青年骨干教师培养计划()
维普
万方数据