Objective To explore the mechanism of Yupingfeng Powder in promoting wound healingwith the use of data min-ing and analysis of drug ingredients and targets of Yupingfeng Powder through network pharmacology and molecular docking. Methods TCMSP databasewas used to search the active ingredients and related targets of YupingfengPowder,and the OMIM,PharmGKB,TTD,DrugBank,and GeneCards databases were used to find related targets. The Perl language was used to classify and analyze the data and the R language was used to draw Venn diagrams according to the data. The STRING network platform was used to retrieve the relationshipsamong target proteins,and the PPI network diagram was derived. The network relationships of active ingredients and disease-related targets were visualized by using Cytoscape software. Bioconductor data and R language were used for data analysis,and correlation bar charts,bubble charts,and path charts were drawn. PubChem database and PDB database were used for receptor and ligand information,and AutoDockTools was used for molecular docking and scoring. Results There were 14 kinds in HedysarumMultijugum Maxim,16 in AtractylodesMacrocephalaKoidz,and 3 kinds in Saposhnikoviae Radix. Eighteen core targets were selected in PPI. GO and KEGG analysis showed that the AGE-RAGE pathway,TNF pathway,EGFR pathway,PI3K-Akt pathway,MAPK pathway,and HIF-1 pathway were all associated with wound healing targets treated by Yupingfeng Powder. There are many active components in Yupingfeng Powder acting on the core target PPARγ,and it is pre-dicted that the active component of Hederagenin may act on PPARγ.Conclusion Yupingfeng Powder is a multi-target,multi-pathway,and multi-mechanism treatment for wound healing. Hederagenin may be a new mechanism to promote wound healing by acting on PPARγ targets.
维普
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