Corn stalks were treated with 11 chemical and biochemical synchronization methods; the breakdown rates of DM, CP and ADF in Tan sheep rumen were measured by means of nylon cannula. The result showed that complex biochemical synchronization treatment was more effective than that of complex chemical treatment. The digestion rate (74.25%) of DM in biochemical synchronization treatment 9 was 22.47% more than that of chemical synchronization treatment 7 (53.54%). The breakdown of CF was 76. 92% in biochemical synchronization treatment 11, which was 17. 31% higher than chemical synchronization treatment 9 (65. 57%). The highest degradation rate of ADF was 75. 12% (biochemical synchronization treatment 9), which doubled the best outcome of chemical synchronization (chemical synchronization treatment 3) by 38. 10%. Comprehensive assessment indicated that biochemical synchronization treatment 9 was the most effective, and both chemical and biochemical synchronization treatments were effective in increasing digestion rate of nutrients of corn stalks.