In order to meet the high requirements of vibration isolation index and layout of the engine room pump set for a quiet ship,the design of the regional vibration module of the engine room pump set of the ship is studied by utilizing the advantages of compact equipment layout,high space utilization and good vibration isolation effect of the regional vibration isolation module.A design calculation and analysis process for the regional vibration isolation module with high vibration isolation performance is established from the aspects of the general arrangement of the regional vibration isolation module,finite element modeling,modal analysis of the middle raft,module modal analysis,module static analysis and module harmonic response analysis.The design of this type of regional vibration isolation module and the calculation and evaluation of vibration isolation index have been completed,and its vibration isolation performance has been tested.The results show that the vibration isolation performance of this type of regional isolation module can meet the design requirements of the high vibration isolation index of the engine room pump set for the quiet ship.