摘要
目的:探讨钙剂、尼麦角林联合氟桂利嗪治疗前庭周围性眩晕的疗效及安全性.方法:选取106例前庭周围性眩晕患者为研究对象,按照治疗方式不同分为A组(n=36)、B组(n=35)和C组(n=35).A组患者给予氟桂利嗪治疗;B组患者给予尼麦角林+氟桂利嗪治疗;C组患者给予钙剂+尼麦角林+氟桂利嗪资料,疗程均为6周.比较各组患者治疗前后眩晕程度[眩晕残障问卷(DHI)评分]、眩晕症状[眩晕症状评分简化量表(VSS-SF)及前庭症状指数(VSI)评分]、血流动力学参数[全血黏度、血细胞比容、椎动脉平均流速(Vm)、基底动脉Vm]、治疗效果、不良反应及治疗6个月后复发情况.结果:治疗后,B组、C组患者DHI躯体、功能及情绪维度评分、VSS-SF评分、VSI评分均低于A组(P＜0.05);临床有效率均高于A组(P＜0.05);全血黏度、血细胞比容均低于A组(P＜0.05);椎动脉Vm、基底动脉Vm高于A组(P＜0.05).各组患者不良反应发生率比较,差异无统计学意义(P＞0.05);治疗6个月后复发率比较,差异有统计学意义(27.78％vs.25.71％vs.5.71％,P＜0.05).结论:钙剂、尼麦角林联合氟桂利嗪治疗前庭周围性眩晕疗效确切,且有利于降低疾病复发风险.
Abstract
Objective:To investigate the efficacy and safety of calcium,niergoline combined with flunarizine in the treatment of peripheral vestibular vertigo.Methods:A total of 106 patients with peripheral vestibular vertigo were selected.They were divided into group A(Flunarizine,n=36),group B(Nyergoline+Flunarizine,n=35)and group C(calcium+Nyergoline+Flunarizine,n=35)according to different intervention methods,all groups were treated for 6 weeks.The degree of dizziness[dizziness handicap inven-tory(DHI)],dizziness symptoms[vertigo symptom scale-short form(VSS-SF),vestibular symptom index(VSI)scores],hemodynam-ic parameters[whole blood viscosity,hematocrit,vertebral artery mean velocity(Vm),basilar artery Vm],treatment effect,adverse re-actions during treatment and recurrence 6 months after treatment were compared among the groups before and after treatment.Results:After treatment,DHI scores,VSS-SF scores and VSI scores of physical,functional and emotional dimensions in group B and group C were lower than those in group A(P＜0.05).After treatment,the clinical effective rate of group B and group C was higher than that of group A(P＜0.05).After treatment,the whole blood viscosity and hematocrit of groups B and C were lower than those of group A(P＜0.05),and the Vm of vertebral artery and basilar artery were higher than those of group A(P＜0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P＞0.05).The recurrence rate of the three groups 6 months after treatment was significantly different(27.78％vs.25.71％vs.5.71％,P＜0.05).Conclusion:Calcium,niergoline combined with flunarizine is effective in the treatment of peripheral vestibular vertigo,and is beneficial to reduce the risk of disease recurrence.
维普
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