Clinical effect of vitamin D assisted with methylphenidate in the treatment of comorbid attention deficit hyperactivity disorder in children with benign epilepsy with centrotemporal spikes
Clinical effect of vitamin D assisted with methylphenidate in the treatment of comorbid attention deficit hyperactivity disorder in children with benign epilepsy with centrotemporal spikes
Objective:To explore the clinical efficacy of vitamin D-assisted methylphenidate in the treatment of children with be-nign epilepsy with centrotemporal spikes(BECTS)complicated with attention deficit hyperactivity disorder(ADHD).Methods:60 children with BECTS and ADHD were selected as the research subjects.According to the different treatment methods,they were divided into control group and combined group,30 cases in each group.The control group was treated with methylphenidate,and the observation group was treated with vitamin D combined with methylphenida,continuous treatment for 3 months.The clinical efficacy,clinical core symptoms[Conners Children's Behavioral Parent Questionnaire(PSQ)],cognitive function[Wechsler Intelligence Scale for Children-Ⅳ(WISC-Ⅳ),Mini-Mental State Examination(MMSE)],serum inflammatory factors[interleukin-6(IL-6),IL-1β,tumor necrosis factor-α(TNF-α)],EEG θ/β ratio and incidence of adverse reactions were compared between the two groups.Results:The total effec-tive rate of combined group was higher than that of the control group(93.33％vs.73.33％,P＜0.05).After 3 months of treatment,the PSQ scores of the two groups were decreased(P＜0.05),and the combined group was lower than the control group(P＜0.05).The scores of WISC-Ⅳ and MMSE of children in the two groups were increased(P＜0.05),and those in the combined group were higher than the control group(P＜0.05).The levels of serum inflammatory factors TNF-α,IL-1 β,IL-6 and EEG θ/β ratio of children in the two groups were decreased(P＜0.05),and those in the combined group were lower than those in the control group(P＜0.05).The total incidence of adverse reactions between the two groups had no significant difference(6.67％vs.13.33％,P＞0.05).Conclu-sion:Vitamin D supplementation on the basis of methylphenidate in the treatment of BECTS children with ADHD can improve the clini-cal efficacy,relieve the clinical core symptoms,improve the cognitive function,reduce the level of inflammation and EEG θ/β ratio,and has good safety.
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