Modification of NiCo2O4 Nanozyme and Antibacterial Properties for Escherichia Coli and Staphylococcus Aureus
Different proportions of Cu-NiCo2O4 nanomaterials were prepared by the solvothermal method using the advan-tages of easy control of bimetallic oxides. The crystal phase,morphology,structure,and functional groups of NiCo2O4 nano-materials were analyzed by XRD,SEM,and FTIR;the effects of ion doping on the crystal phase and morphology of NiCo2O4 nanomaterials were studied;the enzyme-like activity and bacteriostatic properties of NiCo2O4 nanomaterials were studied;and the optimum doping ratio was obtained. Its anti-infective ability and biosafety were studied by a wound model,histopathological analysis,and cytotoxicity tests in mice. Through the above experiments,Cu-NiCo2O4 nanomaterials with a stable crystal phase,a size of 1～2 μm,double enzyme-like activity,high bacteriostatic performance,good biosafety,and a Cu:Ni molar ratio of 0.5％ were obtained.
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