Mechanism of Action and Drug Sensitivity Analysis of DIP2A in Lung Adenocarcinoma
DIP2A is clinically important for the mechanism of action and anticancer drug sensitivity in lung adenocarcinoma.In this stud-y,we mined the TPM-normalized expression matrix of lung adenocarcinoma in the TCGA database,and investigated the effect of this gene on lung adenocarcinoma(LUAD)using bioinformatics methods.The results showed that DIP2A was highly expressed in LUAD;differential gene analysis showed a total of 829 differential genes(DEGs),of which 813 genes were up-regulated and 13 genes were down-regulated in the DIP2A high-expression group,and GO and KEGG analyses indicated that these differential genes were involved in translational activity and miRNAs in cancer.Drug sensitivity analysis screens 11 drugs with negative correlation between IC50 and DIP2A expression,including afatinib,apelalis,PIM inhibitors,Dot1l inhibitors,lincitinib,maleimide analogs,BCL-2 inhibitors,ne-larabine,ositinib,sorafenib,and aurora kinase inhibitors.These drugs may have some inhibitory effect on DIP2A-overexpressing lung adenocarcinomas.
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