Synthesis,structure and Anticancer Studies of Cu(Ⅱ)and Zn(Ⅱ)Complexes Based on 3,5-dichlorosalicylaldehyde-4-aminoantipyrine Schiff Base
The Schiff base ligand,3,5-dichlorosalicylaldehyde-4-aminoantipyrine(HL)was prepared by condensation reaction of 3,5-dichlorosalicylaldehyde and 4-aminoantipyrine,two novel Schiff base complexes[CuL2](complex 1)and[ZnL2](complex 2)were syn-thesized by solvothermal reaction with CuCl2·2H2O and Zn(Ac)2·2H2O.The two complexes were characterized by infrared spectroscopy,thermogravimetric analysis and PXRD.The molecular structures of ligand(HL),complex 1 and complex 2 were determined by Single Crystal X-ray Diffraction.The results showed that Ligand(HL)belongs to monoclinic system with space group P21/n,complex 1 be-longs to monoclinic system with space group C2/c,complex 2 crystals belongs to the monoclinic system with space group P21/c.Among which,Complex1displays tetragonal structure and complex 2 exhibits distorted hexacoordinate octahedral structure.The in vitro antitumor activity of the ligand(HL)and its complexes against three human tumor cell lines(MDA-MB-231,CNE-2Z,A-549)was deter-mined by MTT assay.The results showed that the inhibitory effect of complex 1 on cancer cells was significantly better than that of the ligand.The complex 1 exhibited significant on MDA-MB-231 cells and CNE-2Z cells,with IC50 values of(1.215±0.07)μmol/L and(4.417±0.28)μmol/L respectively,which was lower than that of cisplatin.Complex 2 also showed good anticancer activity against A-549 cells and MDA-MB-231 cells.
NETL
NSTL
万方数据
