Copper-Catalyzed Bicyclization Reaction to Synthesize Five- and Six-Membered Nitrogen Heterocycles
Heterocyclic compounds include nitrogen heterocycles, sulfur heterocycles, silicon heterocycles, phosphorous heterocycles and other different structures. Nitrogen heterocycles are the most common and important heterocyclic compounds. The key nucleus of ac-tive molecules such as Vasicine, Batracylin, Neocryptolepine are all five- and six-membered nitrogen heterocyclic skeletons, showing diverse pharmacological activities. Magnesium, cobalt, nickel and other metals are commonly used catalysts for the synthesis of nitrogen heterocyclics. Compared with the aforementioned metals, copper has the obvious advantages of simple ligands, low toxicity, and mild conditions, which has been widely used in the construction of nitrogen heterocyclic skeletons. This article reports on the construction of a five- and six-membered nitrogen heterocyclic skeleton based on a copper-catalyzed bicyclization reaction, which lays a foundation for exploring new methods for the synthesis of such derivatives.
copper-catalyzedbicyclizationfive- and six-memberednitrogen heterocycles
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维普
