The Reaction of Synthesis of Fused Heterocyclic Compounds by Bicyclization
Cyclic compounds are divided into monocyclic and fused ring according to the form of the ring,and fused ring compounds are divided into different structures such as bicyclic,tricyclic,tetracyclic.Xylarinol A,Cyclomegistine,Mollenine A and other active mole-cules belong to bicyclic,tricyclic and tetracyclic fused compounds,respectively,with outstanding pharmacological activity.This paper reviews the application of bicyclization in the synthesis of fused heterocyclic compounds,involving cyclization expansion,nucleophilic substitution,Friedel-Crafts alkylation and other processes,which greatly expands the diversity of fused heterocyclic compounds.
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维普
