Pharmacokinetics and Toxicity Study of Tetracaine Hydrochloride Gastric/Enteroscopy Lubricant in Beagle Dogs
By administering tetracaine hydrochloride gastric/enteroscopy lubricant with single gavage or rectum,observing the clinical response of the animals,and measuring the concentration of tetracaine hydrochloride in the body,gross necropsy of the main tissue organs was performed,and the weight and co-efficient of the organs were measured in order to understand the pharmacokinetics and toxicity in the ani-mals.8 Beagle dogs were randomly divided into gavage group and rectal group.10 mL tetracaine hydro-chloride gastric/enteroscopy lubricant(tetracaine hydrochloride 80 mg)was administered in gavage or rectum separately.The results show that there are unobvious abnormality,such as signs,behavioral activi-ties,breathing,feces,the feeding and wight grouth of the dogs were pretty normal.Compared with pre-drug administration,each dog had significantly decreasing body temperature,slowing of heart rate,and pro-longed Q-T interval and T wave time at 4 h after drug administration,it was caused by the anesthetic effi-cacy effect of tetracaine hydrochloride.Hematology,blood biochemistry,main organ weight and coefficient and gross dissection of each animal showed no obvious abnormalities;after a single gavage or rectal ad-ministration,the mean Tmax was 0.63 and 0.44 h,the mean t1/2β was 1.20 and 3.36 h;the mean AUC was 60.44 and 60.19 μg/L*h,respectively.This suggested that less amount of drug was absorbed into the blood,and most of the drug remained for local lubrication and anesthesia.
万方数据
维普
