摘要
综述单味中药、中药单体、中药复方及中成药调节细胞因子治疗失眠的进展,为防治失眠提供思路.通过检索国内外数据库从数据库建立至2023年发表的细胞因子调节失眠的相关文献,通过纳入和排除标准共纳入61篇标准文献进行综述.不同类型的中药调节细胞因子治疗失眠的作用机制主要集中在调节ILs和TNF,进而缓解失眠;不同类型的中药可分别调控TLR4/NF-κB信号通路、NLRP3炎性小体通路、SIRT1/NF-κB信号通路、大脑CREB/BDNF/TrkB信号通路和Th1/Th2的分化等,调节炎症因子ILs和TNF的释放,缓解失眠和改善失眠引起的焦虑和认知障碍等并发症.
Abstract
This study aims to review the progress in using single Chinese herbs,traditional Chinese medi-cine(TCM)monomers,TCM formulas,and TCM preparations to regulate cytokines for the treatment of in-somnia,and provide ideas for the prevention and treatment of insomnia.Relevant literature on cytokine regulation of insomnia was retrieved from domestic and foreign databases established from the database es-tablishment to 2023,and 61 standard articles were included in the review through inclusion and exclusion criteria.The mechanisms by which different types of TCM regulate cytokines to treat insomnia mainly fo-cus on regulating ILs and TNF,thereby alleviating insomnia.Different types of TCM can respectively regu-late TLR4/NF-κB signaling pathway,NLRP3 inflammasome pathway,SIRT1/NF-κB signaling pathway,brain CREB/BDNF/TrkB signaling pathway,and Th1/Th2 differentiation,etc.,to modulate the release of inflammatory factors ILs and TNF,and alleviate insomnia and ameliorate the insomnia-induced complica-tions such as anxiety and cognitive disorders.
基金项目
四川省科技厅农业科技成果转化资金项目(2022NZZJ0015)
四川省2021-2023年高等教育人才培养质量和教学改革项目(JG2021-1103)
龙泉驿英才计划C类创新人才计划项目(90)
成都大学附属医院院级课题(Y2021006)
成都大学附属医院院级课题(Y202232)
成都大学附属医院院级课题(Y202234)
成都大学临床医学院/附属医院创新团队项目(CDFYCX202208)
国家科技期刊平台
NSTL
万方数据