首页|中药调节细胞因子水平治疗失眠研究进展

中药调节细胞因子水平治疗失眠研究进展

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
综述单味中药、中药单体、中药复方及中成药调节细胞因子治疗失眠的进展,为防治失眠提供思路.通过检索国内外数据库从数据库建立至2023年发表的细胞因子调节失眠的相关文献,通过纳入和排除标准共纳入61篇标准文献进行综述.不同类型的中药调节细胞因子治疗失眠的作用机制主要集中在调节ILs和TNF,进而缓解失眠;不同类型的中药可分别调控TLR4/NF-κB信号通路、NLRP3炎性小体通路、SIRT1/NF-κB信号通路、大脑CREB/BDNF/TrkB信号通路和Th1/Th2的分化等,调节炎症因子ILs和TNF的释放,缓解失眠和改善失眠引起的焦虑和认知障碍等并发症.
Research Progress in Treatment of Insomnia by Regulating Cytokine Levels in Traditional Chinese Medicine
This study aims to review the progress in using single Chinese herbs,traditional Chinese medi-cine(TCM)monomers,TCM formulas,and TCM preparations to regulate cytokines for the treatment of in-somnia,and provide ideas for the prevention and treatment of insomnia.Relevant literature on cytokine regulation of insomnia was retrieved from domestic and foreign databases established from the database es-tablishment to 2023,and 61 standard articles were included in the review through inclusion and exclusion criteria.The mechanisms by which different types of TCM regulate cytokines to treat insomnia mainly fo-cus on regulating ILs and TNF,thereby alleviating insomnia.Different types of TCM can respectively regu-late TLR4/NF-κB signaling pathway,NLRP3 inflammasome pathway,SIRT1/NF-κB signaling pathway,brain CREB/BDNF/TrkB signaling pathway,and Th1/Th2 differentiation,etc.,to modulate the release of inflammatory factors ILs and TNF,and alleviate insomnia and ameliorate the insomnia-induced complica-tions such as anxiety and cognitive disorders.

insomniatraditional Chinese medicinecytokinesresearch progress

严雪、周文月、周森林、童宇、时政

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成都大学 临床医学院/附属医院,四川 成都 610106

成都大学 食品与生物工程学院,四川 成都 610106

失眠 中药 细胞因子 研究进展

四川省科技厅农业科技成果转化资金项目四川省2021-2023年高等教育人才培养质量和教学改革项目龙泉驿英才计划C类创新人才计划项目成都大学附属医院院级课题成都大学附属医院院级课题成都大学附属医院院级课题成都大学临床医学院/附属医院创新团队项目

2022NZZJ0015JG2021-110390Y2021006Y202232Y202234CDFYCX202208

2024

10.3969/j.issn.1004-5422.2024.02.002

成都大学学报(自然科学版)
成都大学

成都大学学报(自然科学版)

影响因子：0.357
ISSN：1004-5422
年,卷(期)：2024.43(2)
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