Re-Evaluation of Yinzhihuang Granules and Oral Liquid Quality Based on Pharmacodynamic Value
The quality of Yinzhihuang oral liquid and granules will be re-evaluated with the pharmacody-namic value as the index.The active ingredient content wogomin,chlorogenic acid and gardenin were de-termined by using HPLC.Analytic hierarchy process method was also used to evaluate the pharmacodyna-mic effects of Yinzhihuang oral liquid and granules.The efficacy of these two preparations was verified u-sing anti-inflammatory,analgesic,and hepatoprotective pharmacodynamic models.The Yinzhihuang Oral Liquid and Yinzhihuang Granules exhibited anti-inflammatory effects of 20.54 and 20.61 mg,respective-ly,the analgesic effects were 14.37 and 13.66 mg,respectively,and the pharmacodynamic effects on he-patic protection were 28.54 and 24.07 mg,respectively.The in vivo efficacy studies of this research indi-cate that Yinzhihuang Oral Liquid provides liver protection and has a stronger analgesic effect than Yinzhihuang Granules.Additionally,the anti-inflammatory effect of Yinzhihuang Granules was found to be stronger than that of Yinzhihuang Oral Liquid.These results are consistent with the predicted pharmacody-namic values.The pharmacodynamic value can be used as an index for the re-evaluation of the pharmaco-dynamic effect of Yinzhihuang series preparations.
Yinzhihuang series preparationpharmacodynamic effectsanti-inflammatoryanalgesichepa-toprotective
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