Expression of Androgen Receptor and Ki-67 in Triple-negative Breast Cancer and Its Association with Prognosis
Objective To investigate the expression of androgen receptor(AR)and Ki-67 in triple-negative breast cancer,and to study their relationship with patients'prognosis.Methods Eighty-eight female TNBC patients treated at Chaoyang Central Hospital from January 2015 to May 2020 were included in the observation group,while 89 female NTNBC patients were included as a control group.We examined the expression of AR and Ki-67 and observed the differences in their expression in triple-negative breast cancer,and analysed their relationship with patients'prognosis.Results The expression rate of AR in the observation group was lower than that in the control group(P＜0.05),while the expression rate of Ki-67 in the observation group was higher than that in the control group(P＜0.05).The expression of AR and Ki-67 is related to tumor diameter and the number of lymph node metastases(P＜0.05).COX regression analysis showed that pathological grade,number of lymph node metastases,AR and Ki-67 expression were independent influences on the prognosis of triple-negative breast cancer(P＜0.05).Conclusion AR and Ki-67 were closely related to the prognosis of triple-negative breast cancer.Patients with positive AR expression and low Ki-67 expression suggested a better prognosis and longer survival time.
triple negative breast cancerandrogen receptorKi-67prognosis
万方数据
维普
