Changes and Clinical Significance of Serum PIVKA-Ⅱ,CHI3L1 and TFF-1 Levels in Patients with Primary Liver Cancer
Objective To analyze the changes and clinical significance of abnormal serum levels of prothrombine-Ⅱ(PIVKA-Ⅱ),chitosinase 3-like protein-1(CHI3L1)and trefoil peptide factor-1(TFF-1)in patients with primary liver cancer.Methods Ninety-seven patients with liver cancer admitted to our hospital from July 2021 to February 2023 were selected as the study group,and 56 patients with cirrhosis were selected as the control group.The serum levels of PIVKA-Ⅱ,CHI3L1 and TFF1 were compared between the two groups at admission.The serum levels of PIVKA-Ⅱ,CHI3L1 and TFF1 in patients with primary liver cancer were compared with different pathological parameters(tumor diameter,TNM stage and differentiation degree).The correlation and combined diagnostic value of different pathologic parameters with serum PIVKA-Ⅱ,CHI3L1 and TFF1 levels were analyzed.Results The serum levels of PIVKA-Ⅱ,CHI3L1 and TFF-1 in the study group were higher than those in the control group(P<0.05).Comparison of serum PIVKA-Ⅱ,CHI3L1 and TFF1 levels in patients with primary liver cancer with different pathological parameters:tumor diameter(≤5cm)was lower than that of tumor diameter(>5cm),and stage I to Ⅱ was lower than stage III to stage IV(P<0.05);the serum PIVKA-Ⅱ levels in low-differentiated HCC patients were higher than those in medium-differentiated HCC patients,and the serum CHI3L1 and TFF1 levels were lower than those in medium-differentiated HCC patients(P<0.05).At admission,serum PIVKA-Ⅱlevel was positively correlated with tumor diameter and TNM stage,but negatively correlated with differentiation degree(P<0.05).Serum CHI3L1 and TFF1 levels were positively correlated with tumor diameter and TNM stage(P<0.05).At admission,the AUC of serum PIVKA-Ⅱ,CHI3L1 and TFF1 levels combined with the diagnosis of primary liver cancer was 0.903(P<0.05).Conclusion Serum PIVKA-Ⅱ,CHI3L1 and TFF-1 levels are closely related to the disease of patients with primary liver cancer,which can be used as an important reference index for clinical treatment.
isosorbide mononitrateβ-receptor blockeracute myocardial infarctionmyocardial fatty acid binding protein
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