Expression and Clinical Significance of S1PR2,ApoH and Let-7d in Aortic Dissection
Objective To analyze the expression and clinical significance of S1PR2,ApoH and Let-7d in aortic dissection.Methods A total of 60 patients with thoracic and abdominal aortic dissection diagnosed by CTA in Nanyang Central Hospital from January 2021 to September 2023 were selected as the study group,and another 50 healthy subjects during the same period were selected as the control group.The results of digital subtraction angiography (DSA) were used as the gold standard.The patients in the study group were divided into mild group (n=21),moderate group (n=19) and severe group (n=20) according to the severity of the disease.The expressions of S1PR2,ApoH and Let-7d in the two groups were compared,the expressions of S1PR2,ApoH and Let-7d in different levels of the groups,the detection comparison between various detection methods and the combined detection of the three groups,and the ROC curve analysis of S1PR2,ApoH,Let-7d and the combined diagnostic value of the three groups,S1PR2,ApoH and Le Association of t-7d levels with aortic dissection disease.Results Compared with the control group,the expression of S1PR2 and Let-7d in the study group was lower and the expression of ApoH was higher (P＜0.05).The expression of S1PR2 and Let-7d in severe group was lower than that in mild and moderate groups,and the expression of ApoH in severe group was higher than that in mild and moderate groups.In this study,5 cases were positive for S1PR2,6 cases were positive for ApoH and 4 cases were positive for Let-7d,all of which were lower than the number of positive cases for combined testing.The combined AUC value of the three components (0.743) was higher than that of S1PR2 (0.552),ApoH (0.343) and Let-7d (0.493).The combined sensitivity,specificity and accuracy were higher (P＜0.05).Based on the correlation analysis of S1PR2,ApoH,Let-7d and aortic dissection disease,the correlation between S1PR2 and aortic dissection disease showed a negative correlation (r=-5.137,P=0.027),and the correlation between ApoH and aortic dissection disease showed a positive correlation (r=4.211,P=0.044) and Let-7d were negatively correlated with aortic dissection disease (r=-6.291,P=0.016).Conclusion There is a certain correlation between the expression levels of S1PR2,ApoH and Let-7d in aortic dissection diseases.The combination of these three indicators can provide a theoretical basis for guiding the treatment and prognosis evaluation of aortic dissection diseases.
万方数据
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