3D printing technology research of BC/CS composite hydrogel
Hydrogels based on bacterial cellulose(BC)and chitosan(CS)have both high biocompatibility of BC and the antibacterial properties of CS,and have been widely used in wound dressing,tissue engineering and other fields,but their 3D printing is still facing difficulties.The physical properties and cross-linking mechanism of BC and CS are utilized to prepare BC/CS composite hydrogel ink which can be used for 3D printing.At the same time,nano-clay is used as rheological modifier to improve the self-supporting ability of hydrogel.For the cross-linking method,the traditional soaking method is no longer used,instead,glutaraldehyde solution is evenly sprayed on the surface of the printed sample with a sprayer,which may not damage the structure of the sample and can achieve the purpose of cross-linking.Then,a 3D printing system suitable for BC/CS composite hydrogel printing is constructed,and on this basis,the effects of nozzle extrusion pressure,moving speed and printing height on the precision of hydrogel are studied and analyzed.The proposed method is expected to provide guidance for DIW printing of BC/CS composite hydrogels.
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