The lymphatic valve is a critical structure that control flowing of the lymph fluid,and further affects the tumor lymphatic metastasis.The bionic lymphatic valve structure is designed based on the membrane shell theory,and the effects of thickness and elasticity of the valve on its deformation are simulated and analyzed with COMSOL finite element simulation.A mixed material is prepared with PDMS and Ecoflex00-30,by adjusting volume ratio of the two materials,making its Young's modulus more closer to the native tissue.The microchannel with the bionic lymphatic vessel is fabricated by the soft-etching technique,one-way closure performance is tested.The results show that under the pressure of 80 Pa,there is no obvious leakage in bionic lymphatic vessel structure,one-way closure performance is good.
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