Novel electrochemical detection method for highly sensitive 5-HT based on Cu-TCPP
Metal organic frameworks(MOFs)material Cu-TCPP nanosheets are prepared by liquid-phase stripping method using 5,10,15,20-tetra-(4-carboxyphenyl)porphyrin(H2TCPP)as ligand and Cu2+as metal center source.The Cu-TCPP nanosheets modified electrodes(Cu-TCPP/GCEs)are prepared and used in the highly sensitive determination of 5-HT.Compared with bare glassy carbon electrode(GCE),the oxidation current of 5-HT on Cu-TCPP/GCE is significantly increased.The signal enhancement mechanism is researched,and the Cu-TCPP nanosheets effectively improve the enrichment efficiency and electron-transfer-ability of 5-HT.By optimizing the detection conditions,a novel highly sensitive 5-HT electrochemical detection method is successfully established.The linear range is 5～1 000 nmol/L,with the detection limit of 1.33 nmol/L.
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