Optimization of bending effect in capillary electrophoresis based on BOBYQA algorithm
The generation mechanism of the elbow pipe effect during the transport process of the capillary U-bend is analyzed by numerical under simulation,and the influence of elbow pipe effect on concentration pulse under Pe number is analyzed.The zeta potential distribution on the Wall surface of the elbow pipe is optimized based on bound optimization by quadratic approximation (BOBYQA)algorithm.The research results show that the optimization of the Zeta potential distribution on the wall surface of the microchannel elbow pipe can be quickly realized by using the finite element modeling and BOBYQA algorithm,and the effect of the elbow pipe in the microchannel can be effectively suppressed.After optimization,the bandwidth length of concentration pulse is reduced compared with that before optimization,and the velocity distribution of flow field at the elbow pipe is also improved.It has certain reference value for material separation detection and chip design in microfluidic system.
万方数据
维普
