摘要
基于人工表面等离激元效应,提出了一种基于聚合物/金属复合超材料的太赫兹生物分子传感增强方法.通过飞秒激光原位快速加工完成了聚合物/金属复合超材料的制备,低介电常数的聚合物基底显著提升了生物分子—太赫兹—表面微结构的电磁响应强度,实现了葡萄糖标记物的高灵敏度检测.实验结果显示,超材料器件的Q值高达4.11,对于2～10 mmol/L浓度范围内的葡萄糖溶液,传感灵敏度为4.1 THz/(mol·L-1),检测下限为0.085 mmol/L,证明了太赫兹超材料生物传感器在糖尿病标记物检测方面的应用潜力.
Abstract
Based on the artificial surface equipartition excitation effect,a method for enhancing terahertz biomolecular sensing based on polymer/metal composite metamaterials is proposed. Preparation of polymer/metal composite metamaterials is completed by femtosecond laser in-situ rapid processing. Polymer substrates with low dielectric constants significantly enhance the electromagnetic response intensity of biomolecular-terahertz-surface microstructures. High sensitivity detection of glucose markers is achieved. The results show that the Q value of the metamaterial is up to 4.11 and the sensing sensitivity is 4.1 THz/(mol·L-1 )for glucose solutions in the concentration range of 2～10 mmol/L. The lower limit of detection is 0.085 mmol/L. It demonstrates the application potential of terahertz metamaterial biosensors in the detection of diabetes markers.
维普
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