The application of non-Gaussion DWI model in body diseases
When perform diffusion-weighted imaging (DWI) at ultrahigh b-value, the standard monoexponential model analysis may not be suitable. Water molecules diffusion behaviors in the extracellular space away from Gaussian distribution, thus it is requiring a more sophisticated model for analysis the non-Gaussian behaviors of water. Diffusional kurtosis imaging (DKI) can describe this non-Gaussian diffusion effects of water and provide an additional parameter Kapp, which presumably reflects heterogeneity and irregularity of cellular microstructure, as well as the amount of interfaces within cellular tissue. A few studies have explored DKI outside the brain in rencent years. The most investigated organ is the prostate. Studies have shown that DKI can improve tumor detection and grading. A robust understanding of DKI is necessary for radiologists to better understand the meaning of DKI parameters in the context of different tumors and how these parameters vary between tumor types and in response to treatment. This article reviewed the basic principle, biological correlation, technique highlights and the clinical application in the body of DKI.
Non-GaussianDiffusionmagneticresonanceimagingDiffusional kurtosis imagingHuman Body
国家科技期刊平台
NSTL
万方数据
维普
