目的 使用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)技术研究原发性闭角型青光眼(primary angle-closure glaucoma,PACG)患者在静息状态下百分比波动振幅(percent amplitude of fluctuation,PerAF)的变化.材料与方法 共纳入江西省人民医院眼科诊断的PACG患者31例.同期,31名性别、年龄、受教育时间与之匹配的健康对照(healthy control,HC)被纳入对照组.对每个受试者进行全脑rs-fMRI扫描,以收集PerAF信号.分别采用单样本t检验和双样本t检验比较各组组内和组间PerAF数据.结果 与HC组相比,PACG患者组在左侧额上回背外侧(t=-3.9421,P＜0.001)、眶部(t=-3.4619,P＜0.001),左侧眶部额中回(t=-3.6709,P＜0.001),右侧额中回(t=-3.8257,P＜0.001),右侧额下回三角部(t=-3.6708,t=-4.0375,P＜0.001);左侧缘上回(t=-3.9570,P＜0.001)、顶下缘角回(t=-3.8230,t=-3.8730,P＜0.001),右侧顶上回(t=-4.4581,P＜0.001)、中央后回(t=-3.7825,P＜0.001),中央旁小叶(r=-4.0816,P＜0.001);右侧颞中回(t=-3.8402,P＜0.001);左侧舌回(t=-3.5758,P＜0.001);左侧前扣带和旁扣带脑回(t=-3.4718,P＜0.001)、补充运动区(t=-3.7209,P＜0.001)以及右侧小脑下部7b区(t=-3.9479,P＜0.001)的PerAF均显著降低(体素水平P＜0.001,聚类水平P＜0.05,高斯随机场校正).结论 PACG患者在多个大脑区域存在异常的PerAF值,涉及与视觉、情绪和认知调节相关的初级和高级视觉皮层和大脑区域.
Percent amplitude of fluctuation study in primary angle-closure glaucoma based on resting-state fMRI
Objective:To study the changes of percentage fluctuation amplitude(PerAF)in patients with primary angle-closure glaucoma(PACG)at rest using resting-state functional magnetic resonance imaging(rs-fMRI)technique.Materials and Methods:A total of 31 cases of PACG patients diagnosed in the ophthalmology department of Jiangxi Provincial People's Hospital were included.During the same period,31 sex,age,and duration of education-matched healthy controls(HC)were included in the control group.Whole-brain rs-fMRI scans were performed on each subject to collect PerAF signals.One-sample t-test and two-sample t-test were used to compare PerAF data across and between groups,respectively.Results:Compared with HC group,subjects in the PACG patient group had significantly lower PerAF in the left supraparietal gyrus(t=-3.9421,P＜0.001),orbital(t=-3.4619,P＜0.001),left orbital median frontal gyrus(t=-3.6709,P＜0.001),bilateral right median frontal gyrus(t=-3.8257,P＜0.001),right inferior frontal gyrus deltoid(t=-3.6708,t=-4.0375,P＜0.001);left supramarginal gyrus(t=-3.9570,P＜0.001),inferior parietal marginal angular gyrus(t=-3.8230,t=-3.8730,P＜0.001),right superior parietal gyrus(t=-4.4581,P＜0.001),postcentral gyrus(t=-3.7825,P＜0.001),and paracentral lobule(t=-4.0816,P＜0.001);right middle temporal gyrus(t=-3.8402,P＜0.001);left lingual gyrus(t=-3.5758,P＜0.001);left anterior cingulate and paracingulate cingulate gyrus(t=-3.4718,P＜0.001),supplementary motor area(t=-3.7209,P＜0.001),and right inferior cerebellar area 7b(t=-3.9479,P＜0.001)(P＜0.001 at voxel level,P＜0.05 at cluster level,Gaussian random field corrected).Conclusions:Patients with PACG have abnormal PerAF values in multiple brain regions involving primary and higher visual cortex and brain regions associated with visual,emotional,and cognitive regulation.
glaucomaprimary angle-closure glaucomaresting-state functional magnetic resonance imagingpercent amplitude of fluctuationmagnetic resonance imaging
万方数据
维普
