Value of ZOOM-mDixon-derived T2*/R2*imaging in preoperative predicting lymph node metastasis in pancreatic ductal adenocarcinoma
Objective:To investigate the feasibility of using quantitative T2*/R2*values derived from the ZOOM-mDixon sequence for evaluating lymph node metastasis in pancreatic ductal adenocarcinoma.Materials and Methods:A retrospective analysis was conducted on 59 patients with pathologically confirmed pancreatic ductal adenocarcinoma,including 31 patients with lymph node metastasis(LNM)and 28 patients without lymph node metastasis(nLNM).All patients underwent preoperative MRI scans,which included the ZOOM-mDixon sequence.The analysis involved examining clinical data,such as age and preoperative carbohydrate antigen(CA)19-9 levels,routine radiological features including location and morphology,and T2*/R2*values.Intra-class correlation coefficients(ICC)were used to evaluate repeatability,while U-tests,t-tests,or χ2 tests were used to compare differences between the two groups.The receiving operator characteristic(ROC)curve was plotted,and the area under curve(AUC)was calculated to assess the diagnostic performance of quantitative indicators.Results:The inter-and intra-group ICC values for T2*/R2*were excellent,ranging from 0.83 to 0.97.No statistically significant differences were observed in age,tumor morphology,short diameter of the tumor,tumor location,preoperative CA19-9,CA125,carcinoma embryonic antigen(CEA)levels between the LNM and nLNM groups.However,gender,long diameter of the lesion,and lesion boundary exhibited statistically significant differences(P values were 0.023,0.048,0.040,respectively).There were significant statistical differences in the T2*and R2*values between the two groups(P values＜0.05).Compared with the nLNM group,the LNM group exhibited a smaller R2*value[17.63(15.10,22.50)/s vs.24.00(20.00,28.30)/s]and a higher T2*value[(63.77±13.95)ms vs.(49.71±12.67)ms].The AUCs for T2*/R2*values in predicting lymph node metastasis of pancreatic cancer were 0.775 and 0.766,respectively.Conclusions:Quantitative T2*/R2*imaging derived from the ZOOM-mDixon sequences can predict preoperative lymph node metastasis of pancreatic ductal adenocarcinoma,offering valuable insights for clinical treatment decisions.
万方数据
