The value of APT imaging in evaluating the therapeutic efficacy of concurrent chemoradiotherapy for cervical cancer
Objective:To explore the value of amide proton transfer(APT)imaging in evaluating the efficacy of concurrent chemoradiotherapy(CCRT)for cervical cancer.Material and Methods:A retrospective analysis was conducted on 27 patients with cervical cancer confirmed by pathology.The efficacy of CCRT was evaluated based on the evaluation criteria for solid tumor efficacy.Complete remission(CR)and partial remission(PR)were included in the remission group,while disease stability(SD)and disease progression(PD)were included in the non-remission group.The values of apparent diffusion coefficient(ADC)and ATP of the lesion area were compared and analyzed before and after CCRT,as well as in the remission and non-remission groups.The correlation between ADC value,APT value,and CCRT efficacy were analyzed by using Pearson correlation analysis.Results:After CCRT,there were 3 cases of CR(11.11％),16 cases of PR(59.26％)and 8 cases of SD(29.63％)in 27 patients with cervical cancer.The local control rate was 100.00％.Compared with before CCRT,the ADC value of the lesion after CCRT increased[(0.89±0.06)×l0-3 mm2/s vs.(1.07±0.07)× 10-3 mm2/s,P＜0.05]and the APT value decreased significantly(3.30％±0.05％vs.3.07％±0.07％,P＜0.05).Before CCRT,the values of ADC and APT in the remission group were higher than those in the non-remission group,and the difference was not statistically significant(P＞0.05);After CCRT,the ADC value of the remission group was higher than that of the non-remission group[(1.10±0.06)× 10-3 mm2/s vs.(1.01±0.04)×10-3 mm2/s,P＜0.05],while the APT value of the remission group was lower than that of the non-remission group(3.05％±0.06％vs.3.12％±0.07％,P＜0.05).There is a significant negative correlation between the ADC value after CCRT and the efficacy of CCRT(r=-0.61,95％CI:-0.82--0.39,P＜0.01),while there is a significant positive correlation between APT value and CCRT efficacy(r=0.50,95％CI:0.20-0.76,P=0.01).Conclusions:CCRT for cervical cancer has a good therapeutic effect.The APT value is positively correlated with the CCRT effect and an effective imaging marker for reflecting the efficacy of CCRT in cervical cancer.
cervical cancermagnetic resonance imagingamide proton transfer imagingapparent diffusion coefficientchemoradiotherapyefficacy evaluation
万方数据
维普
