Quantitative assessment of skeletal muscle fat content in type 2 diabetic patients by magnetic resonance multi-echo DIXON technique
Objective:Using the magnetic resonance multi-echo DIXON(mDIXON)technique analyze the differences between thigh muscle and paravertebral muscle fat content between patients with type 2 diabetes mellitus(T2DM)and healthy controls and explore the relationship of each skeletal muscle fat content with duration,triglyceride glucose(TyG)index,and other indicators.Materials and methods:The study prospectively enrolled 42 clinically diagnosed T2DM patients and 44 age,gender,and recruitment-matched healthy volunteers as the control group.All subjects underwent thigh and abdomen mDIXON sequence scanning.An independent-sample t-test was employed to compare the fat fraction(FF)values of each muscle group between the two groups.Multivariate linear regression and logistic regression analyses were conducted to assess the correlation between FF values,duration of diabetes,and TyG index.Results:The FF values of all thigh muscle groups in the T2DM group were higher than those in the control group,and the FF value of the quadratus lumborum was significantly higher than that in the healthy control group(t=3.402,P＜0.001).There was no significant difference in the FF value of the other paravertebral muscles between the two groups(P＞0.05).The thigh muscle FF values of females in the T2DM group were significantly higher than those of males(P＜0.001).The FF values of vastus lateralis,vastus medialis,and rectus femoris in the T2DM group were positively correlated with the course of the disease(r=0.057,0.073,0.125,P＜0.001).Increased FF values of erector spinae and vastus lateralis are a risk factor for a high TyG index(OR=1.934,P＜0.001;OR=2.516,P＜0.001).Conclusions:The mDIXON sequence has a good ability to evaluate skeletal muscle fat content.Skeletal muscle fat content is higher in patients with T2DM than in healthy people.Combined with the course of the disease and TyG index,further analysis of the changes in skeletal muscle fat content in T2DM patients is helpful to guide the clinical diagnosis and treatment of T2DM patients.
type 2 diabetes mellitusskeletal musclefat quantificationmagnetic resonance imaging
万方数据
维普
