阿尔茨海默病(Alzheimer's disease,AD)是以认知障碍为特征的中枢神经系统退行性疾病,出现临床症状前有长达约20年的临床前期,是AD干预的最佳时间窗,因此早期诊断对延缓病情和改善预后至关重要.静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)具有无创性和高时空分辨率等优势,是研究AD脑功能活动异常最广泛使用的神经成像技术之一,为寻找早期AD非侵入性标记物提供了可能.本文就rs-fMRI技术在AD早期诊断的应用价值进行综述,以期找到早期监测AD的非侵入性影像学标记物.
Abstract
Alzheimer's disease(AD)is a degenerative disease of the central nervous system characterized by cognitive impairment.There is a preclinical period of approximately 20 years before the onset of clinical symptoms,making it the optional time window for disease intervention.Therefore,the early diagnosis of AD is essential for disease delay and prognosis improvement.Resting-state functional magnetic resonance imaging(rs-fMRI)has the advantages of non-invasive and high spatial-temporal resolution.It is one of the most widely used neuroimaging techniques to study brain functional activity abnormalities in AD,which provides the possibility to find non-invasive markers of early AD.Based on rs-fMRI techniques,we reviewed the application value in the early diagnosis of AD in this article,in order to find non-invasive imaging markers for early monitoring of AD.
维普
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