烟雾病(moyamoya disease,MMD)是一种病因不明的进行性狭窄或闭塞性脑血管疾病,认知障碍是其较常见的一种伴随症状.功能磁共振成像(functional magnetic resonance imaging,fMRI)能够从脑血流动力学、脑微结构及脑功能网络等多个方面对MMD患者进行无创性评价,从不同角度揭示MMD患者认知障碍的病理生理机制.本文就磁共振灌注加权成像(perfusion weighted imaging,PWI)、扩散张量成像(diffusion tensor imaging,DTI)、神经突方向离散和密度成像(neurite orientation dispersion and density imaging,NODDI)以及血氧水平依赖 fMRI(blood oxygenation level dependent fMRI,BOLD-fMRI)技术原理及其在MMD认知障碍中的应用进展进行综述,以期为MMD认知障碍病理生理机制的进一步研究提供参考方向,并为MMD认知障碍的早期诊断、治疗和评估奠定理论基础.
Advances in functional MRI in cognitive impairment of moyamoya disease
Moyamoya disease(MMD)is a progressive stenotic or occlusive cerebrovascular disease of unknown etiology,and cognitive impairment is one of the more common accompanying symptoms.Functional magnetic resonance imaging(fMRI)can noninvasively evaluate the cerebral hemodynamics,brain microstructure,and brain functional networks of MMD patients,and reveal the pathophysiological mechanisms of cognitive impairment in MMD patients from different perspectives.This article reviews the technical principles of perfusion weighted imaging(PWI),diffusion tensor imaging(DTI),neurite orientation dispersion and density imaging(NODDI),and blood oxygenation level dependent fMRI(BOLD-fMRI)and their application in MMD cognitive impairment.In order to provide a reference direction for the further study of the pathophysiological mechanism of MMD cognitive impairment,and lay a theoretical foundation for the early diagnosis,treatment and evaluation of MMD cognitive impairment.
moyamoya diseasefunctional magnetic resonance imagingmagnetic resonance imagingcognitive impairment
万方数据
维普
