Diabetes peripheral neuropathy(DPN)is a relatively common chronic complication of diabetes mellitus,which seriously affects the quality of life of patients.The pathogenesis of DPN is complex,and current studies have shown that it is closely related to neuropathic changes.In recent years,multimodal magnetic resonance imaging(MRI)has achieved long progress.MRI is famous for its high soft tissue resolution,non-invasive,non-radiation,and has become an important method to explore the pathogenesis of central and peripheral nerves in DPN.In this paper,voxel-based morphometry(VBM),diffusion tensor imaging(DTI),and functional MRI(fMRI)are applied to review the literature on the study of DPN brain structure,brain function changes,and peripheral nerve structure abnormalities.The literature on DPN brain structure,brain function changes,and peripheral nerve structure abnormalities will be reviewed to provide a basis for early clinical diagnosis and precise treatment plans.