冻结步态(freezing of gait,FOG)是一种可见于帕金森病中晚期患者的阵发性步态障碍,极大地影响了患者的生活质量,但针对其发病机制以及病程中脑结构功能变化至今尚无明确的阐述.近年来以扩散张量成像(diffusion tensor imaging,DTI)、三维T1加权成像(3D T1-weighted imaging,3D-T1WI)和功能MRI(functional MRI,fMRI)为主的多模态MRI技术广泛运用于神经性疾病发病机制的探究,为探索FOG的深层机制提供了新思路.近年来研究显示,视觉、运动和认知网络的改变与FOG的发生紧密相关.笔者旨在通过查阅分析近年国内外相关文献,对多模态MRI探索帕金森病FOG患者脑结构和功能变化的研究进行综述,讨论当前FOG研究仍值得商榷之处,为今后通过多模态MRI更全面解释其发病机制提供新的思路.
Research progress on freezing of gait in Parkinson's disease based on multimodal MRI
Freezing of gait(FOG)is a paroxysmal gait disturbance observed in patients with advanced-stage Parkinson's disease,significantly impacting their quality of life.However,there is still no clear elucidation of the pathogenesis and changes in brain structure and function during the course of the disease.In recent years,multimodal MRI imaging techniques,primarily utilizing diffusion tensor imaging(DTI),three-dimensional T1-weighted imaging(3D T1WI)and functional MRI(fMRI)have been widely employed in the exploration of the pathogenesis of neurological disorders.These techniques have provided new insights into the underlying mechanisms of FOG.Recent research indicates a close association between changes in visual,motor,and cognitive networks and the occurrence of FOG.The author aims to conduct a review by analyzing recent domestic and international literature,summarize multimodal MRI exploration of structural and functional changes in the brains of Parkinson's disease patients with freezing of gait.The review discusses the current controversial aspects of FOG research and proposes new perspectives for future comprehensive elucidation of its pathogenesis using multimodal MRI.
Parkinson's diseasefreezing of gaitdiffusion tensor imagingmagnetic resonance imagingfunctional connectivitybrain network
万方数据
维普
