Application progress of neuromelanin-sensitive MRI in Parkinson's disease
Neuromelanin-sensitive magnetic resonance imaging(NM-MRI)is an emerging non-invasive technique utilized to visualize changes in neuromelanin(NM)within the brain.It exhibits sensitivity to the reduction or variation of intracranial neuromelanin levels.Parkinson's disease(PD),a prevalent neurodegenerative disorder,is characterized by the degeneration of dopamine neurons containing NM in the substantia nigra,resulting in a decrease in NM.Consequently,the detection of variations in NM-MRI of the substantia nigra can serve as an indirect indicator of the functional state of dopamine neurons.Role of NM-MRI in the diagnosis of PD cannot be ignored,furthermore,this paper reviews the recent advancements in NM-MRI research pertaining to the imaging of PD,with the objective of offering enhanced reference value for future related investigations,it is expected that with the maturity of NM-MRI technology,it will become an imaging tool to assist in clinical PD diagnosis and contribute to the study of the pathological mechanisms of PD.
Parkinson's diseaseneuromelaninsubstantia nigraneuromelanin-sensitive magnetic resonance imagingmagnetic resonance imaging
万方数据
维普
