产后女性脑镜像同伦功能连接改变的静息态fMRI研究
Alterations of brain mirror homotopic functional connectivity in postpartum women:A resting-state fMRI study
张凯华 1林嘉玉 1宿薇 1高樱莉 1李娜 1杜钰煊 1蔺星儒 1王晶 2赵诗佳 1杜小霞3
作者信息
- 1. 山东师范大学心理学院,济南 250014
- 2. 山东师范大学留学出国培训基地,济南 250014
- 3. 上海体育大学心理学院,上海 200438
- 折叠
摘要
目的 基于体素镜像同伦连接(voxel-mirrored homotopic connectivity,VMHC)方法研究产后女性和未育女性大脑中同位点之间的功能连接差异,探索产后女性脑功能变化.材料与方法 收集39名初次生育完后的女性和26名未育女性的静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)数据及结构像数据进行VMHC分析,并采用双样本t检验分析组间VMHC差异.同时收集两组人口统计学数据和人际反应指针量表(Interpersonal Reactivity Index-C,IRI-C)评分.结果 IRI-C量表分析发现产后女性和未育女性在共情关心上存在显著性差异(P<0.001).与未育女性组相比,产后女性组在双侧梭状回、海马旁回、额中回、额内侧回、中央前回、壳核和豆状核等脑区的VMHC值表现出显著降低(FDR校正,体素水平P<0.001,团块水平P<0.05,双尾),在双侧楔前叶、顶上小叶和顶下小叶的VMHC值显著增加(FDR校正,体素水平P<0.01,团块水平P<0.05,双尾).结论 初次生育后的女性部分脑区半球间功能连接发生改变,这可能是女性为产后期间的养育行为做出的适应性变化.
Abstract
Objective:Voxel-mirrored homotopic connectivity(VMHC)was used to study the difference of functional connection between parity points in the brain of postpartum women and nulliparous women to explore the changes of brain function of postpartum women.Materials and Methods:The resting-state functional magnetic resonance imaging(rs-fMRI)data and structural image data of 39 postpartum women and 26 nulliparous women were collected for VMHC analysis,and the differences of VMHC between groups were analyzed by a two-sample t-test.Moreover,the demographic data and Interpersonal Reactivity Index-C(IRI-C)scores of the two groups were collected.Results:The analysis of the IRI-C scale found a significant difference in empathy between postpartum women and nulliparous women(P<0.001).Compared with the nulliparous women,the postpartum women showed significantly decreased VMHC in bilateral fusiform gyrus,parahippocampal gyrus,middle frontal gyrus,medial frontal gyrus,anterior central gyrus,putamen and lentiform nucleus and other brain regions(FDR corrected,voxel level P<0.001,cluster level P<0.05,two tailed),while they showed significantly increased VMHC in bilateral precuneus,parietal lobules and subparietal lobules(FDR corrected,voxel level P<0.01,cluster level P<0.05,two tailed).Conclusions:After giving birth for the first time,the functional connections between hemispheres in some brain regions of women have changed,which may be the adaptive changes of women's parenting behavior during the postpartum period.
关键词
产后女性/未育女性/母婴依恋/静息态功能磁共振成像/体素镜像同伦连接Key words
postpartum women/nulliparous women/maternal and infant attachment/resting-state functional magnetic resonance imaging/voxel-mirrored homotopic connectivity引用本文复制引用
基金项目
国家自然科学基金(32200915)
山东省自然科学基金(ZR2022QC251)
出版年
2024
国家科技期刊平台
NSTL
万方数据