首页|4D-Flow MRI在肥厚型心肌病左室流出道血流评估中的价值探索

4D-Flow MRI在肥厚型心肌病左室流出道血流评估中的价值探索

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原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的 探索四维血流(four-dimensional flow,4D-Flow)磁共振成像(magnetic resonance imaging,MRI)技术在左心室腔内应用的可行性.材料与方法 本研究为前瞻性、横断面研究,纳入2022年8月至2023年1月于我院接受心脏MRI检查的21例肥厚型心肌病患者,采用3.0 T MRI扫描仪进行二维血流(tow-dimensional flow,2D-Flow)及4D-Flow成像,收集患者一周内进行的超声心动图检查结果.采用组内相关系数(inter-class correlation coefficient,ICC)、变异系数(coefficients of variation,COV)及Bland-Altman分析比较2D-Flow、4D-Flow评估左室流出道峰值流速的可重复性及一致性,并通过Pearson相关性分析探究二者与超声心动图测量结果的关系.结果 2D-Flow和4D-Flow观察者内/观察者间的ICC分别为0.999/0.999和0.995/0.992,COV分别为0.5%/0.5%和2.4%/2.6%.4D-Flow与超声心动图的测量结果呈中度相关,相关系数r值为0.574(P=0.006),但一致性较差,ICC为0.375(P=0.013).2D-Flow与4D-Flow和超声心动图间无显著的一致性及相关性.结论 4D-Flow技术能够可视化心腔内血流模式,对左室流出道峰值流速的测量具有高度可重复性,且与超声心动图的测量结果具有显著的一致性.
Value of 4D-Flow MRI in evaluating left ventricular outflow tract peak velocity in hypertrophic cardiomyopathy:A proof-of-concept study
Objective:To explore the feasibility of using four-dimensional flow(4D-Flow)magnetic resonance imaging(MRI)in left ventricle,and to evaluate the reproducibility and consistency of quantification of left ventricular outflow tract(LVOT)peak velocity by comparing with two-dimensional flow(2D-Flow)MRI and echocardiography.Materials and Methods:This research was a prospective and cross-sectional study.Twenty-one patients with hypertrophic cardiomyopathy(HCM)underwent cardiac MRI 2D-Flow and 4D-Flow data acquisition on a 3.0 T MRI scanner August 2022 to January 2023.Echocardiography within one weeks before or after MRI examination were collected.The inter-class correlation coefficient(ICC),coefficient of variation(COV)and Bland-Altman analysis were used to evaluate the reproducibility and consistency of LVOT peak velocity derived from 2D-Flow and 4D-Flow,and the relationship between 2D/4D-Flow and echocardiography was analyzed by Pearson correlation analysis.Results:The ICC of 2D-Flow and 4D-Flow were 0.999/0.999 and 0.995/0.992,respectively,and the COV of 2D-Flow and 4D-Flow were 0.5%/0.5%and 2.4%/2.6%,respectively.4D-Flow was moderately correlated with echocardiography(r=0.574,P=0.006),but the consistency between the two was poor(ICC= 0.375,P=0.013).Besides,there were no significant consistency and correlation between 2D-Flow and 4D-Flow/echocardiography.Conclusions:4D-Flow cardiac MRI can visualize the flow patterns within the heart.The peak velocity of LVOT derived from 4D-Flow is highly reproducible and is significantly correlated with echocardiography.

hypertrophic cardiomyopathyfour-dimensional flowtwo-dimensional flowcardiac magnetic resonancemagnetic resonance imaging

徐晶、陈秀玉、尹刚、闫伟鹏、陆敏杰、赵世华

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中国医学科学院,北京协和医学院阜外医院磁共振影像科,北京 100037

肥厚型心肌病 四维血流 二维血流 心脏磁共振 磁共振成像

国家重点研发计划国家重点研发计划国家自然科学基金高水平医院临床科研青年重点项目

2021YFF05014002021YFF0501404819300442022-GSP-QZ-5

2024

10.12015/issn.1674-8034.2024.03.010

磁共振成像
中国医院协会 首都医科大学附属北京天坛医院

磁共振成像

CSTPCD北大核心
影响因子：1.38
ISSN：1674-8034
年,卷(期)：2024.15(3)
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