目的 采用Meta分析方法探讨初始T1值及细胞外容积分数(extracellular volume fraction,ECV)对心脏淀粉样变性(cardiac amyloidosis,CA)的诊断价值.材料与方法 检索数据库PubMed、Embase、Cochrane Library、Web of Science、Wanfang Database、CBM、VIP及CNKI中有关探讨初始T1值及ECV对CA诊断价值的文献,检索时间为从建库开始至2022年11月.由2名研究者单独完成文献筛选,提取纳入文献的相关资料并进行质量评估.应用Revman 5.3、Stata 16.0和Meta-Disc 1.4软件进行偏倚风险评价和统计分析,进行异质性、发表偏倚分析.使用敏感性分析验证Meta分析结果的稳定性与可靠性.结果 最终纳入文献12篇,共1 045例患者.Meta分析显示初始T1值诊断CA的合并敏感度(sensitivity,Sen)、特异度(specificity,Spe)、阳性似然比(positive likelihood ratio,PLR)、阴性似然比(negative likelihood ratio,NLR)、诊断比值比(diagnostic odds ratio,DOR)、曲线下面积(area under the curve,AUC)和95%置信区间(confidence interval,CI)分别为86%(95%CI:82%～89%)、86%(95%CI:80%～91%)、6.2(95%CI:4.2～9.3)、0.16(95%CI:0.12～0.22)、38(95%CI:19～75)、0.92(95%CI:0.90～0.94);ECV诊断CA的Sen合并、Spe合并、PLR合并、NLR合并、DOR合并、AUC分别为90%(95%CI:83%～94%)、90%(95%CI:83%～94%)、8.8(95%CI:5.3～14.6)、0.11(95%CI:0.07～0.19)、79(95%CI:38～162)、0.95(95%CI:0.93～0.97).结论 初始T1值和ECV对CA具有较高的诊断价值,可为CA的早期诊断提供影像学依据.
Diagnostic value of native T1 and ECV in myocardial amyloidosis:A Meta-analysis
Objective:The Meta-analysis was used to explore the diagnostic value of native T1 and extracellular volume fraction(ECV)for cardiac amyloidosis(CA).Materials and Methods:PubMed,Embase,Cochrane Library,Web of Science,Wanfang Database,CBM,VIP and CNKI were searched to explore the value of T1 and ECV of the diagnostic value in CA.The search time was from the establishment of the database to November 2022.Two researchers independently completed the literature screening,extracted the relevant data included in the literature and evaluated the quality.The bias risk was evaluated and statistically analyzed by Revman 5.3,Stata 16.0 and Meta-Disc 1.4.Heterogeneity and publication bias analysis were carried out.Sensitivity analysis was used to verify the stability and reliability of Meta-analysis results.Results:A total of 12 articles(1 045 patients)were included.Meta-analysis showed that sensitivity(Sen),specificity(Spe),positive likelihood ratio(PLR),negative likelihood ratio(NLR),diagnostic odds ratio(DOR),area under the curve(AUC)and 95%confidence interval(CI)of T1 diagnostic CA were 86%(95%CI:82%-89%),86%(95%CI:80%-91%),6.2(95%CI:4.2-9.3),0.16(95%CI:0.12-0.22),38(95%CI:19-75),0.92(95%CI:0.90-0.94).The Sen,Spe,PLR,NLR,DOR,and AUC of ECV diagnostic CA were 90%(95%CI:83%-94%),90%(95%CI:83%-94%),8.8(95%CI:5.3-14.6),0.11(95%CI:0.07-0.19),79(95%CI:38-162),and 0.95(95%CI:0.93-0.97).Conclusions:Native T1 value and ECV have high diagnostic value for CA and can provide imaging basis for the early diagnosis of CA.
cardiac amyloidosiscardiac magnetic resonanceT1 mappingextracellular volume fractionMeta-analysis
国家科技期刊平台
NSTL
万方数据
