昼夜节律在脑的多模态MRI中的研究进展
Research progress on circadian rhythms in multimodal MRI of the brain
邢寒棋 1戴慧2
作者信息
- 1. 苏州大学附属第一医院放射科,苏州 215006
- 2. 苏州大学附属第一医院放射科,苏州 215006;苏州大学医学影像研究所,苏州 215006;苏州市智能医学与装备重点实验室,苏州 215123
- 折叠
摘要
昼夜节律的存在使大脑结构、功能发生昼夜波动.目前大多数神经影像学研究没有控制一天中的时间这个生物变量,使结果的可重复性降低以及解释复杂化.近年来,随着多模态MRI快速发展,基于体素的形态学测量(voxel-based morphometry,VBM)、扩散MRI(diffusion MRI,dMRI)、功能MRI(functional MRI,fMRI)、磁共振波谱(magnetic resonance spectroscopy,MRS)及动脉自旋标记(arterial spin labeling,ASL)等方法被用于研究昼夜节律对大脑结构及功能的影响.大多数研究发现时间对大脑结构和功能存在显著的影响,但报告的结果存在不一致.目前的研究仅关注了白天的时间点和一天中2～3个时间点,缺少对夜间时间点和一天中多个时间点的研究.笔者对近年来昼夜节律在脑的MRI中的研究进展进行综述,以提高大家对时间作为影响神经影像学研究的生物变量的认识.
Abstract
The presence of circadian rhythms causes diurnal fluctuations in brain structure and function.Currently,most neuroimaging studies do not control for the biological variable of time of day,making results less reproducible as well as complicating interpretation.In these years,the rapid development of multimodal MRI,voxel-based morphometry(VBM),diffusion magnetic resonance imaging(dMRI),functional magnetic resonance imaging(fMRI),magnetic resonance spectroscopy(MRS),and arterial spin labeling(ASL)methods have been used to study the influence of circadian rhythm on brain structure and function.Most studies have found significant effects of time of day on brain structure and function,but there are inconsistencies in the results reported.Current research has focused only on daytime time points and two or three-time points during the day,lacking research on nighttime time points and multiple time points during the day.We provide a review of recent progress in the study of circadian rhythms in MRI of the brain in order to increase awareness of time as a biological variable that influences neuroimaging studies.
关键词
昼夜节律/脑结构/脑功能/多模态/磁共振成像Key words
circadian rhythm/brain structure/brain functional/multimodality/magnetic resonance imaging引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据