Research progress of multimodal MRI in deep brain stimulation therapy for Parkinson's disease
Parkinson's disease(PD),which is characterized by resting tremor,muscular tonus,bradykinesia,and postural balance abnormalities,is the second most prevalent neurodegenerative disease in middle-aged and older persons worldwide.Its incidence is expected to increase to double in the following three decades.As the negative effects of medicines become increasingly evident,deep brain stimulation(DBS)has gained popularity as a novel type of adjuvant therapy.Magnetic resonance imaging(MRI)can non-invasively provide information on the structure,function,and metabolism of brain tissues in vivo,which is of greater clinical significance for assessing the effects of DBS after treatment of PD and guiding therapy.Therefore,this article provides a review of the research progress of multimodal MRI,including structural magnetic resonance imaging(sMRI),diffusion tensor imaging(DTI),blood oxygenation level dependent-functional magnetic resonance imaging(BOLD-fMRI),susceptibility-weighted imaging(SWI),quantitative magnetic susceptibility mapping(QSM),and magnetic resonance spectroscopy(MRS)in the treatment of PD with DBS,with the aim of assisting the clinic in choosing efficient and safe treatment methods and correctly evaluating the therapeutic effects.
Parkinson's diseasemagnetic resonance imagingdeep brain stimulationbrain structurebrain function
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