静息态功能磁共振成像在癫痫中的研究进展
Research progress of resting state functional magnetic resonance imaging in epilepsy
郭佳慧 1吴琼 1高阳 1赵鹤 1谢生辉 1李波 1王少彧 2张华鹏 2王桠楠1
作者信息
- 1. 内蒙古医科大学附属医院影像诊断科,呼和浩特 010030
- 2. 西门子医疗系统有限公司,上海 201318
- 折叠
摘要
癫痫是一种慢性神经系统疾病,其分类广泛、机制复杂,具有反复发作和不可预测的特点,对患者的生活造成了一定的影响.深度了解其病理生理机制对疾病的治疗和提高患者生活质量十分重要,静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)现已成为探究癫痫脑功能改变的有效方法.目前基于rs-fMRI研究癫痫的数据分析方法主要有低频振幅(amplitude of low frequency fluctuation,ALFF)、局部一致性(regional homogeneity,ReHo)、功能连接(function connection,FC)和图论分析.本文将对rs-fMRI的各种分析方法在癫痫中的应用作一综述,为癫痫的病理生理机制及术前定位、治疗提供重要参考.
Abstract
Epilepsy is a chronic neurological disease,its classification is wide,the mechanism is complex,has the characteristics of repeated seizures and unpredictable,which has caused a certain impact on the life of patients.Therefore,it is necessary to understand the pathophysiological mechanisms for the treatment of epilepsy and the improvement of patients'quality of life.Resting-state functional magnetic resonance imaging(rs-MRI)has become an effective method to investigate the changes of brain function in epilepsy.At present,the data analysis methods for epilepsy research based on rs-fMRI mainly include amplitude of low frequency fluctuation(ALFF),regional homogeneity(ReHo),function connection(FC)and graph theory analysis.This article provides a review of the application of various rs-fMRI analysis methods in epilepsy,aiming to provide imaging indicators for the pathophysiological mechanism,preoperative and precise clinical treatment of epilepsy.
关键词
癫痫/磁共振成像/静息态功能磁共振成像/低频振幅/局部一致性/功能连接/图论Key words
epilepsy/magnetic resonance imaging/resting-state functional magnetic resonance imaging/amplitude of low frequency fluctuation/regional homogeneity/function connection/graph theory引用本文复制引用
基金项目
内蒙古医科大学面上项目(YKD2022MS047)
出版年
2024
国家科技期刊平台
NSTL
万方数据