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脑类淋巴系统磁共振成像的临床应用及研究进展

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类淋巴系统(glymphatic system,GS)是脑内新发现的废物清除系统,GS的损伤与多种神经系统疾病密切相关.MRI因具有高度软组织分辨率及多模态成像的优点,被广泛运用于GS的成像研究中.以MRI为主的影像技术为GS的动力学、结构以及相关疾病的研究提供了重要依据.笔者将简要介绍GS解剖与生理功能,并对GS的成像技术及其在神经系统疾病中的应用进展进行综述,旨在提示GS功能障碍在神经影像学研究中的重要性并为GS相关神经系统疾病的诊治及预后提供帮助.
Advances in the clinical application of MRI in the glymphatic system of the brain
The glymphatic system(GS)is a recently discovered mechanism of brain waste elimination,and its disruption is strongly associated to a variety of neurological diseases.The GS has been widely studied using MRI because of its advantages of high soft tissue resolution and multimodal imaging.Providing a substantial basis for the research of the kinetics and structure of the GS and related diseases,MRI contributes as the principal imaging technique.The author will present an overview of the GS and highlight recent advances in MRI of the GS and their application in the investigation of neurological diseases,aiming to stress the importance of glymphatic dysfunction in neuroimaging investigations and provide help for the diagnosis,treatment and prognosis of neurological diseases related to the GS.

glymphatic systemmagnetic resonance imagingdiffusion tensor imagingnervous system disease

沈文卓、李勇刚

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三峡大学基础医学院,宜昌 443002

苏州大学附属第一人民医院放射科,苏州 215006

类淋巴系统 磁共振成像 扩散张量成像 神经系统疾病

江苏省卫生与健康委员会重点科研项目江苏省研究型医院学会感染与炎症放射学会专委会科研基金苏州大学苏州医学院医学+X项目

K2023027GY202301ML12203423

2024

磁共振成像
中国医院协会 首都医科大学附属北京天坛医院

磁共振成像

CSTPCD北大核心
影响因子:1.38
ISSN:1674-8034
年,卷(期):2024.15(3)
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