阿尔茨海默病相关血脑屏障的影像学研究进展
Progress in imaging research on the blood-brain barrier associated with Alzheimer's disease
王兵兵 1罗与 1白岩 2吴亚平 2申雨 2王梅云1
作者信息
- 1. 郑州大学人民医院医学影像科,郑州 450003;河南省人民医院医学影像科,郑州 450003
- 2. 河南省人民医院医学影像科,郑州 450003
- 折叠
摘要
阿尔茨海默病(Alzheimer's disease,AD)是老年人痴呆的最常见原因,其发病机制尚不明确.研究发现,血脑屏障(blood-brain barrier,BBB)损伤与AD的病理学密切相关,在AD的发病机制中发挥着重要作用.影像学技术是探索BBB结构及功能改变的有效方法.本文将就BBB损伤与AD病理学之间的内在联系及多种影像学技术在其中的应用现状进行综述,以期为AD的早期诊断及治疗提供新的思路.
Abstract
Alzheimer's disease(AD)is the most common cause of dementia in the elderly people,and its pathogenesis remains unclear.Research has found that blood-brain barrier(BBB)injury is tightly associated with AD pathology and plays a crucial role in the pathogenesis and progression of AD.Imaging technology is an effective method for exploring changes in the structure and function of BBB.This article will summarize the internal relationship between BBB injury and AD pathology and the current application status of imaging technology in it,in order to provide new ideas for the early diagnosis and treatment of AD.
关键词
阿尔茨海默病/血脑屏障/磁共振成像/正电子发射计算机断层显像/磁共振引导聚焦超声Key words
Alzheimer's disease/blood-brain barrier/magnetic resonance imaging/positron emission tomography/magnetic resonance-guided focused ultrasound引用本文复制引用
基金项目
河南省医学科技攻关计划项目(SBGJ202101002)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据