首页|基于脑-小脑连接梯度的AD患者脑功能层级结构变化研究

基于脑-小脑连接梯度的AD患者脑功能层级结构变化研究

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原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的 采用基于梯度的方法分析阿尔茨海默病(Alzheimer's disease,AD)大脑皮层组织沿脑-小脑连接梯度的功能层级结构及其与小脑相互作用的改变,以及与认知功能障碍之间的联系.材料与方法 基于AD神经影像学计划(Alzheimer's Disease Neuroimaging Initiative,ADNI)公开数据库,共纳入33名AD患者和46名年龄、性别相匹配的健康对照(healthy controls,HC).采用梯度计算方法,通过对所有被试的脑-小脑静息态功能连接矩阵进行非线性分解,得到了每个被试的脑-小脑功能连接梯度.采用双样本t检验进行组间的脑-小脑梯度分数差异分析,以及梯度异常的脑区与小脑功能连接的组间比较,并采用相关分析评估了异常的梯度分数以及功能连接值与临床量表分数的相关性.结果 与HC组相比,AD组在涉及高级认知功能区域右侧颞下回(right inferior temporal gyrus,RITG)(t=4.71,P<0.001)的梯度分数发生局部性改变,进一步基于梯度异常脑区为种子点的功能连接分析显示出RITG到小脑双侧Crus Ⅱ区域以及延伸到的Ⅶ B区(右侧:t=-4.89,P<0.001,左侧:t=-4.98,P<0.001)功能连接的降低.临床量表相关性分析显示,AD患者的梯度异常脑区的连接梯度分数与社会活动功能(Functional Activity Questionnaire,FAQ)评分密切相关(r=0.40,P=0.025).结论 AD患者参与高级认知功能的局部区域功能层级结构的异常变化及其与小脑双侧Crus Ⅱ和Ⅶ B脑区的功能连接降低可能是认知功能受损的潜在因素之一.
Changes of cerebral functional hierarchy in AD patients based on cerebral-cerebellar connectivity gradients
Objective:To analyze the functional hierarchy of Alzheimer's disease(AD)cerebral cortex along the brain-cerebellar connectivity gradient and its altered interaction with the cerebellum and the association with cognitive dysfunction using a gradient-based approach.Materials and Methods:A total of 33 AD patients and 46 age,sex matched healthy controls(HC)were included based on the publicly available database ANDI.The cerebral-cerebellar functional connectivity gradient of each subject was obtained by nonlinearly decomposing the cerebral-cerebellar resting-state functional connectivity matrix of all subjects,using gradient computation method.Two-sample t-tests were performed to analyze differences of cerebral-cerebellar gradient scores between groups,as well as group's comparisons of functional connectivity between abnormal regions of gradients and cerebellar,and correlation analyses were used to assess the correlation of abnormal gradient scores and connectivity values with scores on clinical scales.Results:Compared with healthy controls,AD patients had locally altered gradient scores in the right inferior temporal gyrus(RITG)(t=4.71,P<0.001)which involved in higher cognitive functions,and further functional connectivity analyses based on the gradient-abnormal cerebral region as a seed point showed functional connectivity of RITG to the bilateral Crus Ⅱ region and extending to the Ⅶ B region of the cerebellum(right:t=-4.89,P<0.001;left:t=-4.98,P<0.001)was reduced.Clinical scale correlation analyses showed that connectivity gradient scores in gradient-abnormal brain regions were strongly correlated with Functional Activity Questionnaire(FAQ)scores(r=0.40,P=0.025)in AD patients.Conclusions:The abnormal changes in the functional hierarchy of locoregional areas involved in higher cognitive function in AD patients and their reduced functional connectivity with bilateral cerebellar CrusⅡ and Ⅶ B regions may be one of the potential factors for cognitive impairment.

Alzheimer's diseasecerebral-cerebellar connection gradientresting-state functional connectivitymagnetic resonance imagingfunctional hierarchy

何美荣、莫贤、游晚芳、孙昂、张俊然

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四川大学电气工程学院,成都 610065

西北民族大学电气工程学院,兰州 730030

阿尔茨海默病 脑-小脑连接梯度 静息态功能连接 磁共振成像 功能层级结构

国家自然科学基金四川省科技计划德阳科技(揭榜)项目四川大学"医学+信息"中心融合创新项目琶洲实验室(黄浦)数学与医疗健康交叉重点专项中央高校基本业务费专项西北民族大学项目

1212660623ZDYF29132021JBJZ007YGJC0122023K060531920230132

2024

10.12015/issn.1674-8034.2024.05.001

磁共振成像
中国医院协会 首都医科大学附属北京天坛医院

磁共振成像

CSTPCD北大核心
影响因子：1.38
ISSN：1674-8034
年,卷(期)：2024.15(5)
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