首页|多模态多参数磁共振成像在脑胶质瘤Ki-67表达中的研究

多模态多参数磁共振成像在脑胶质瘤Ki-67表达中的研究

扫码查看
原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的 探讨多模态磁共振成像技术及其定量和定性参数预测胶质瘤Ki-67表达水平的价值.材料与方法 选取330例胶质瘤患者,其中异柠檬酸脱氢酶(isocitrate dehydrogenase,IDH)野生型201例,IDH突变型129例.获得常规MRI特征、表观扩散系数(apparentdiffusion coefficient,ADC)、动态对比增强(dynamic contrast-enhanced,DCE)MRI定性及定量参数时间-强度曲线(time-intensity curve,TIC)、转运常数(volume transfer constant,Ktrans)、渗出速率常数(the rate constant,Kep)、血管外细胞外容积分数(fractional volume of the extravascular-extracellular,Ve)、血浆分数(plasma fraction,Vp)及磁共振波谱(magnetic resonance spectroscopy,MRS)代谢产物比值,对胶质瘤患者进行logistic回归,以确定与Ki-67表达水平相关因素.用受试者工作特征曲线下面积(area under the curve,AUC)评价预测模型的性能.结果 在胶质瘤患者分析中,Ktrans(OR=1.012,P<0.001)、ADC(OR=0.998,P<0.05)、强化程度(OR=3.317,P<0.05)是Ki-67 表达水平的独立预测因素,AUC为 0.893.结论 Ktrans、ADC和强化程度可能是预测胶质瘤Ki-67表达水平的有效参数.
Research of Ki-67 expression in glioma by multimodal multi-parameter magnetic resonance imaging
Objective:To investigate the prediction of Ki-67 expression in glioma by multi-modal magnetic resonance imaging and quantitative and qualitative parameters.Materials and Methods:Three hundred and thirty patients with glioma were selected,including 201 patients with isocitrate dehydrogenase(IDH)wild type and 129 patients with IDH mutant type.Conventional MRI features,apparent diffusion coefficient(ADC),qualitative and quantitative parameters of dynamic contrast-enhanced(DCE)MRI such as time-intensity curves(TIC),volume transfer constant(Ktrans),the rate constant(Kep),fractional volume of the extravascular-extracellular(Ve),plasma fraction(Vp)and magnetic resonance spectroscopy(MRS)metabolites were obtained.Logistic regression was performed for all gliomas to identify factors associated with Ki-67 expression.The area under receiver operating characteristic curve(AUC)was used to evaluate the performance of the prediction model.Results:In glioma patients'analyses,Ktrans(OR=1.012,P<0.001),ADC(OR=0.998,P<0.05),enhancement degree(OR=3.317,P<0.05)were independent predictors of Ki-67 expression level,and AUC value is 0.893,respectively.Conclusions:Ktrans,ADC and enhancement may be effective parameters for predicting Ki-67 expression level in glioma.

gliomamagnetic resonance imagingmulti-modalKi-67isocitrate dehydrogenase

周佳南、朱正阳、田传帅、杨惠泉、陈思璇、叶梅萍、张鑫、张冰

展开 >

南京医科大学鼓楼临床医学院医学影像科,南京 210008

南京大学医学院附属鼓楼医院医学影像科,南京 210008

胶质瘤 磁共振成像 多模态 Ki-67 异柠檬酸脱氢酶

江苏省研究生科研与实践创新计划Fundings for Clinical Trials from the Affiliated Drum Tower Hospital of Medical School of Nanjing University江苏省研究生科研与实践创新计划南京鼓楼医院临床研究专项

JX220141552022-LCYJ-MS-25JX220141552022-LCYJ-MS-25

2024

10.12015/issn.1674-8034.2024.05.007

磁共振成像
中国医院协会 首都医科大学附属北京天坛医院

磁共振成像

CSTPCD北大核心
影响因子：1.38
ISSN：1674-8034
年,卷(期)：2024.15(5)
  • 35