Application of ADC values to assess inflammatory lymph nodes in the drainage area of the salivary glands of patients with primary Sjogren's syndrome
Objective:To investigate the apparent diffusion coefficient(ADC)and morphology of lymph nodes in the drainage area of salivary glands among patients with primary Sjögren's syndrome(pSS)before and after treatment and healthy volunteer,and its potential in reflecting the degree of inflammatory activity of the disease in patients with pSS.Materials and Methods:A total of 23 patients with pSS were collected to undergo routine head and neck MRI and diffusion weighted imaging(DWI)before and after 12 weeks of regular treatment,respectively.ADC images were obtained after post-processing.Then 15 healthy volunteers were collected as controls during the same period.Using t-test to compare the morphology and ADC values of the lymph nodes in each level among the pSS patients before and after treatment,and healthy volunteers.Results:The short diameters of lymph nodes in level Ⅰb,Ⅱa,and Ⅱb in patients with pSS before treatment were larger than those of healthy volunteers[Ⅰb(t=2.293,P=0.028),Ⅱa(t=2.397,P=0.022),Ⅱb(t=1.409,P=0.030)],and the short diameters of lymph nodes in all salivary gland drainage levels were smaller after 12 weeks of treatment[Ⅰa(t=4.391,P<0.001),Ⅰb(t=3.439,P=0.002),Ⅱa(t=3.458,P=0.002),Ⅱb(t=4.667,P=0.001)].ADC values of lymph nodes in level Ⅰb and Ⅱa in pSS patients before treatment were smaller than those of healthy volunteers[Ⅰb(t=3.337,P=0.002),Ⅱa(t=2.207,P=0.038)],and they became larger than those of lymph nodes in level Ⅰa,Ⅰb,and Ⅱa after 12 weeks of treatment[Ⅰa(t=3.674,P=0.001),Ⅰb(t=2.198,P=0.039),Ⅱa(t=2.484,P=0.004)].Conclusions:The short diameters of lymph nodes in level Ⅰb,Ⅱa and Ⅱb may be of great value in identifying patients with pSS and healthy volunteers,and the short diameters of lymph nodes in all levels may be of great value in identifying patients with pSS before and after treatment;the ADC values of lymph nodes in level Ⅰb and Ⅱa may be of great value in identifying patients with pSS and healthy volunteers,and the ADC values of lymph nodes in level Ia,Ⅰb and Ⅱa may be of great value in identifying patients with pSS before and after treatment.
autoimmune diseaseprimary Sjögren's syndromeinflammatory activity of the diseasediffusion weighted imagingapparent diffusion coefficientmagnetic resonance imaging
国家科技期刊平台
NSTL
万方数据
