Advances in the application of resting-state functional magnetic resonance imaging in adolescent-onset schizophrenia
Adolescent-onset schizophrenia belongs to the category of early-onset schizophrenia,which refers to schizophrenia with onset between the ages of 13-18 years old.Compared with adult-onset schizophrenia,its symptoms are more atypical and severe,its response to antipsychotic medications is poorer,and its etiology and pathogenesis are not yet clear.Resting-state functional MRI(rs-fMRI)is a convenient,noninvasive and objective MRI technique that is easy for subjects to cooperate with,and it can reflect the spontaneous activity of brain neurons both locally and holistically,providing a powerful means for the study of the neuropathological mechanisms of AOS.In this paper,we review the latest progress in the application of rs-fMRI in the study of AOS from the aspects of functional segregation analysis and functional integration analysis,discuss the shortcomings of the current study,and look forward to the direction of further research in the future,with the aim of providing certain clues and bases for further exploring the pathophysiological mechanisms of schizophrenia.
schizophreniaadolescentmagnetic resonance imagingresting-state functional magnetic resonance imaging
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