针刺四关穴治疗轻度认知障碍多模态MRI研究进展
Progress in multimodal MRI research on acupuncture at Siguan point for the treatment of mild cognitive impairment
韩盛旺 1李晓陵 2王杨 2侯玉 3魏泽宜 4高胜兰 4王珑5
作者信息
- 1. 黑龙江中医药大学附属第二医院康复三科,哈尔滨 150001;黑龙江中医药大学研究生院,哈尔滨 150040
- 2. 黑龙江中医药大学附属第一医院CT磁共振科,哈尔滨 150040
- 3. 哈尔滨市中医医院妇科,哈尔滨 150020
- 4. 黑龙江中医药大学研究生院,哈尔滨 150040
- 5. 黑龙江中医药大学附属第一医院针灸三科,哈尔滨 150040
- 折叠
摘要
轻度认知障碍(mild cognitive impairment,MCI)是阿尔茨海默病(Alzheimer's disease,AD)的前期阶段,主要症状是学习和记忆能力降低,日常生活却未受影响.针刺四关穴治疗MCI疗效确切,临床应用较广;通过针刺可以改善认知功能,但起效原理复杂.多模态MRI因对MCI异常脑区具有定位精准和实时观测的优势,为针刺四关穴治疗MCI脑效应研究及疗效判定提供可视化支持.本文从结构MRI(structural MRI,sMRI)、扩散张量成像(diffusion tensor imaging,DTI)、血氧水平依赖功能磁共振成像(blood oxygen level dependent functional MRI,BOLD-fMRI)、磁共振波谱(magnetic resonance spectroscopy,MRS)、动脉自旋标记(arterial spin labeling,ASL)五个方面,对针刺四关穴治疗MCI脑结构、脑功能、脑代谢、脑血流灌注的相关文献进行综述,从多个视角探讨MCI脑内变化,剖析针刺治疗的机制,为MCI的后续研究提供新思路.
Abstract
Mild cognitive impairment (MCI) is the early stage of Alzheimer's disease (AD), characterized by decreased learning and memory abilities, with no impact on daily life. Acupuncture at Siguan point has a definite therapeutic effect on MCI and is widely used in clinical practice; acupuncture can improve cognitive function, but the principle of action is complex. Multimodal MRI provides visual support for the study of brain effects and efficacy assessment of acupuncture at the Siguan point in the treatment of MCI due to its advantages of precise localization and real-time observation of abnormal brain regions.In this article, structural MRI (sMRI), diffusion tensor imaging (DTI), blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI), magnetic resonance spectroscopy (MRS), and arterial spin labeling (ASL) were introduced to review the literature on cerebral structure, function, metabolism and blood perfusion of MCI treated by acupuncture at Siguan point. The intracerebral changes of MCI were discussed from multiple perspectives and the mechanism of acupuncture treatment was analyzed, it provides new ideas for the follow-up research of MCI.
关键词
阿尔茨海默病/轻度认知障碍/针刺四关穴/磁共振成像/结构磁共振成像/功能磁共振成像/弥散张量成像/磁共振波谱/动脉自旋标记Key words
Alzheimer's disease/mild cognitive impairment/acupuncture at Siguan point/magnetic resonance imaging/structural magnetic resonance imaging/functional magnetic resonance imaging/diffusion tensor imaging/magnetic resonance spectroscopy/arterial spin labeling引用本文复制引用
基金项目
国家自然科学基金项目(82074537)
国家自然科学基金项目(81303044)
黑龙江省自然科学基金联合引导项目(LH2020H103)
黑龙江省自然科学基金联合引导项目(LH2022H082)
黑龙江省卫生健康委科研项目(20222020011109)
黑龙江省中医药学会青年人才托举工程项目(2022-QNRC1-31)
黑龙江中医药大学研究生创新科研项目(2023yjscx30)
出版年
2024
国家科技期刊平台
NSTL
万方数据