儿童、青少年抑郁症的静息态功能磁共振成像研究进展
Advances in resting-state fMRI studies of depression in children and adolescents
吴蓉 1凌奥南 1张高峰1
作者信息
- 1. 遵义医科大学第二附属医院医学影像科,遵义 563000
- 折叠
摘要
儿童、青少年抑郁症是一种严重的心理健康问题,它会影响儿童、青少年的思维、感觉和行为,并可能导致情绪、功能和身体等方面的问题.抑郁症病因及病理生理机制不明,目前,MRI技术是研究其病因与病理生理机制的主要方法之一.功能MRI(functional MRI,fMRI)能够实时反映脑功能变化,可用于探索儿童、青少年抑郁症患者相关脑区的功能活动.静息态fMRI(resting-state fMRI,rs-fMRI)是目前研究神经影像学的一项热门研究技术,为探讨儿童、青少年抑郁症异常脑区的功能改变提供了影像学支持.本文简要总结近年来青少年抑郁症rs-fMRI研究结果及潜在不足,旨在为今后的研究提供方向.
Abstract
Childhood and adolescent depression is a serious mental health problem that affects the way children and adolescents thinks, feels, and behaves, and can lead to emotional, functional, and physical problems. The etiology and pathophysiologic mechanisms of depression are unknown, and currently, MRI is one of the main methods to study its etiology and pathophysiologic mechanisms. Functional MRI (fMRI) reflects real-time changes in brain function and can be used to explore the functional activity of relevant brain regions in children and adolescents with depression. Resting-state fMRI (rs-fMRI) is currently a popular research technique for studying neuroimaging, which provides imaging support for exploring the functional alterations of abnormal brain regions in children and adolescents with depression. In this paper, we briefly summarize the results and potential shortcomings of rs-fMRI studies of adolescent depression in recent years, aiming to provide directions for future research.
关键词
抑郁症/儿童/青少年/静息态功能磁共振成像/磁共振成像Key words
depression/children/adolescent/resting-state functional magnetic resonance imaging/magnetic resonance imaging引用本文复制引用
基金项目
贵州省科技计划项目(黔科合基础-ZK[2021]一般480)
出版年
2024
国家科技期刊平台
NSTL
万方数据