首页|MRI影像组学在乳腺癌新辅助治疗疗效评价及预后的研究进展

MRI影像组学在乳腺癌新辅助治疗疗效评价及预后的研究进展

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乳腺癌发病率已跃居全球肿瘤性病变首位,且仍呈上升趋势.新辅助治疗(neoadjuvant therapy,NAT)已被广泛应用于局部晚期乳腺癌患者的一线治疗.磁共振成像(magnetic resonance imaging,MRI)具有良好的软组织和空间分辨力,在评估病灶范围、早期诊断、疗效预测和预后评估中越来越重要;基于MRI的影像组学可以分析肉眼无法分辨的内部纹理特征,在评估肿瘤异质性方面具有显著优势.研究已证实乳腺癌NAT疗程不同时间点MRI评估各有优劣,多时序评估较单一时序更精准.本综述旨在探讨在影像组学的支持下纵向时间MRI图像评价NAT疗效的研究现状、存在争议及应用前景,以及MRI影像组学预测乳腺癌患者NAT远期预后的挑战.本研究提示多序列纵向时间MRI图像影像组学模型评估肿瘤反应的优越性,为未来影像组学更多分析方法提供思路.
Research progress of MRI radiomics in the efficacy evaluation and prognosis of neoadjuvant therapy for breast cancer
The incidence of breast cancer has jumped to the top of the global neoplastic lesions,and the incidence is still on the rise. Neoadjuvant therapy (NAT) has been widely used as the first-line treatment for patients with locally advanced breast cancer. Magnetic resonance imaging (MRI), with its good soft tissue and spatial resolution, is increasingly important in assessing lesion extent, early diagnosis, efficacy prediction, and prognostic assessment. MRI-based radiomics can analyze internal texture features that cannot be distinguished by the naked eye, which has great advantages in assessing tumor heterogeneity. Studies have demonstrated the advantages and disadvantages of MRI assessment at different time points of the NAT course in breast cancer, with multi-temporal assessment being more advantageous than single-temporal. The aim of this review is to investigate the current research status, controversies and application prospects of longitudinal temporal MRI images for evaluating neoadjuvant efficacy with the support of imaging histology, as well as the unique advantages of MRI imaging histology for predicting the long-term prognosis of neoadjuvant therapy in breast cancer patients. This study suggests the superiority of the multiseries longitudinal imaging histology model to evaluate tumor response, and provides ideas for more analysis methods of imaging histology in the future.

radiomicsbreast cancerneoadjuvant therapyefficacyprognosismagnetic resonance imaging

白颖楠、周蓉艳、宁子睿、李卓琳

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云南省肿瘤医院(昆明医科大学第三附属医院)放射科,昆明 650118

影像组学 乳腺癌 新辅助治疗 疗效 预后 磁共振成像

2024

磁共振成像
中国医院协会 首都医科大学附属北京天坛医院

磁共振成像

CSTPCD北大核心
影响因子:1.38
ISSN:1674-8034
年,卷(期):2024.15(6)
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